Where should I look?
A short, clickable list of residues with the strongest structural reasons to investigate first.
PRIORITIZED RESIDUESProtein science, made testable.
Find the residue
worth testing.
RINet turns protein structures into an inspectable argument and the experiment that could prove it wrong. Graph theory and residue interaction networks only. No AI.
1,863downloads
Deterministicrepeatable results
Localruns on your device
01 / Run locally
One command.
Your structures stay yours.
macOS · Python 3.11–3.13 · opens in your browser · runs on your computer
One PDB to startNo accountNo structure upload
02 / What you get
Upload one PDB.
Know what to test next.
RINet finds residues that stand out in the supplied structure, explains them in biological language, suggests a comparison residue, and turns the result into a practical experiment plan.
FROM STRUCTURE TO EXPERIMENTOne continuous analysis
01Read the structurechains · missing atoms · confidence fields
02Prioritize residueslocal contacts · position · structural context
03Design a fair testcandidate · matched comparison · mutation options
OUTPUTWhat to change, what to measure, and what result would change your mind.
03 / The guidance
Built for decisions,
not dashboards.
Why might it matter?
Plain-language explanations connect each residue to nearby contacts, structural position and data quality.
BIOLOGICAL CONTEXTWhat should I test?
Mutation ideas, a matched comparison residue, measurements and a step-by-step experimental outline.
EXPERIMENT GUIDEWhat would disprove it?
Every hypothesis includes the result that would weaken it, so a ranking never masquerades as proof.
DECISION RULE04 / Try it now
One PDB in.
An experiment guide out.
Drop a PDB, enter a PDB ID, or run the instant demo. See the 3D surface, what the protein may be useful for, the experiment worth running, comparison controls and a methods-ready record. Deterministic graph theory produces the guidance. No AI model is involved, and your coordinates stay in the browser.
EXPERIMENT GUIDE / 1CRNANALYZED LOCALLY
FIRST LOOKARG A:10
WHYContact-dense, structurally connected position
COMPARE WITHLower-contact residue in a similar context
TESTCandidate perturbation + matched control
READOUTFunction · expression · folding
GUIDANCE READY · NO ACCOUNT REQUIRED
05 / Contact
Questions, ideas,
or feedback.
Ask a question, share what you tried, report a problem, or suggest what RINet should do next. Short notes are welcome.